Download Advances in Chronic Kidney Disease 2010: 12th International by P. Kotanko, N. W. Levin, C. Ronco PDF

By P. Kotanko, N. W. Levin, C. Ronco

The court cases of the overseas convention on Dialysis, geared up through the Renal study Institute, manhattan, are released every year in "Blood Purification". one of the subject matters mentioned within the present quantity are: the possibility of erythropoiesis-stimulating brokers for tissue safety; remedy of high blood pressure in dialysis sufferers; the aptitude position of gelsolin in dialysis-related protein-energy losing; salt restrict in dialysis sufferers; blood-pressure-independent results of aldosterone on nonepithelial tissues; development of the process heart problems by way of modulating immune reaction; the opportunity of intestinal healing interventions to minimize uremic toxin iteration and absorption; the 'obesity paradox' in dialysis sufferers; the importance of endothelial progenitor cells and endothelial vesicles in CKD; the administration of calcium stability in continual dialysis sufferers; and, the function of peripheral ultrafiltration within the administration of acute decompensated middle failure. final yet no longer least, a number of papers are devoted to local citrate anticoagulation instead to systemic heparin anticoagulation. targeting contemporary advancements in operational parts, expertise, biology of uremia and epidemiology, this ebook is a valuable reference instrument for either clinicians and easy investigators fascinated with CKD.

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Additional info for Advances in Chronic Kidney Disease 2010: 12th International Conference on Dialysis, New Orleans, La., January 2010. Special Issue: Blood Purification 2010, Vol. 29, No. 2

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The circulating levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 can potentially influence the activity of many tissues and cells that have a vitamin D receptor and have no function in regulating calcium homeostasis and bone health. These include, among others, the cardiomyocytes, active T and B lymphocytes, mononuclear and endothelial cells [45]. As discussed, dialysis patients on different types of activated vitamin D and analogs [33] have a survival advantage, probably related to the systemic activation of vitamin D receptors, acting as a negative endocrine regulator of renin-angiotensin synthesis [4] and inflammation and reducing cardiac hypertrophy [32].

This article aims to give an appreciation of the possibility that modification of the dialysis treatment to improve tolerability of therapy may have the potential to provide us with additional therapeutic targets, to reduce currently excessive rates of cardiovascular morbidity and mortality. Copyright © 2010 S. Karger AG, Basel Introduction It is well recognised that dialysis patients display hugely elevated rates of cardiac mortality [1]. It is also becoming appreciated that this rate of cardiovascular attrition is not driven by the same variety of risk factors or pathophysiological processes that are important in the general population [2].

Classical complicated atherosclerotic disease appears not to be the predominant mode of death in haemodialysis (HD) patients. This increase in cardiovascular mortality is driven by a combination of sudden cardiac death and heart failure. The development or aggravation of heart failure is associated with a particularly low survival [3]. It has long been suspected that myocardial ischaemia may be precipitated by HD. Short intermittent HD treatments exert significant haemodynamic effects, and 20– Dr.

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