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By Alton Meister

Advances in Enzymology and similar parts of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative stories of the most recent discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, delivering an unmatched view of the old improvement of enzymology. The sequence bargains researchers the newest realizing of enzymes, their mechanisms, reactions and evolution, roles in advanced organic approach, and their program in either the laboratory and undefined. every one quantity within the sequence gains contributions via top pioneers and investigators within the box from all over the world. All articles are conscientiously edited to make sure thoroughness, caliber, and clarity.

With its wide selection of subject matters and lengthy ancient pedigree, Advances in Enzymology and comparable components of Molecular Biology can be utilized not just via scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition through any scientist attracted to the invention of an enzyme, its houses, and its purposes.

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Arnold, W . J . , Jones, R . , and Kelley, W . , Purine Metab. in Man, in press (1 973). 135. Long, W . , Science, 155, 712 (1967). 136. Long, W . , Am. Soc. Hum. Genet. , October 1970, p. 14a. ENZYMOLOGY OF GOUT 33 137. , J . Clin. , 48, 1957 (1 969). 138. , Science, 165, 613 (1969). 139. , Riario-Sforza, G . , 72, 17 (1969). 140. Rowe, P. , and Wyngaarden, J . ,]. B i d . , 247, 5571 (1966). 141. , in press. 142. Gutman, A. , and Yu, T. , Amer. J. , 35, 820 (1963). 143. Pollak, V. , J. Lab. Clin.

M . , Exp. Cell. , 64, 9 (1971). 120. Rosenbloom, F. , Henderson, J . , Caldwell, L. , Kelley, W . , and Seegmiller, J . , /. Bid. , 243, 1166 (1968). 121. Schulman, J . , Greene, M . , Fujimoto, W . Y . , and Seegmiller, J . , Pediatr. , 5, 77 (1971). 122. Rosenbloom, F. , Henderson, J . , Kelley, W . , and Seegmiller, J. , Biochim. Biophys. Actu, 166,258 (1968). 123. Nuki, G . , and Seegmiller, J. , Purine Metab. zn Man, in press (1973). 124. , Lapes, M . , Thomson, C . , and Wright, E. , Clin.

J Clin. , 47, 2281 (1968). 159. Fox, I. H . , Meade, J. , and Kelley, W . , Am. J. , 55, 614 (1973). 160. , Purine Metab. in Man, in press (1974). 161. Emmerson, B. , Gordon, R . , Purine Metab. in Man, in press (1974). 162. Watts, R. W. , Klinenberg, J . , Seegmiller, J . , and Sjoerdsrna, A,, Biochem. , 90, 4 (1964). Advances in Enzymology and Related Areas ofMolecular Biology, Volume 41 Edited by Alton MeisteI Cowright © 1974 bv John Wilev & Sons. Inc. SUPEROXIDE DISMUTASES By IRWIN FRIDOVICH, Durham, North Carolina CONTENTS I.

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