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By P Brandtzaeg, K Bjerke, T S Halstensen, M Hvatum, K Kett, P Krajci, D Kvale, F Müller (auth.), Thomas T MacDonald PhD MRCPath, Stephen J Challacombe PhD BDS MRCPath, Paul W Bland PhD, Christopher R Stokes PhD, Richard V Heatley MD MRCP, Allan Mcl Mowat Ph

The immunology of mucosal surfaces is without doubt one of the most enjoyable and suitable parts of clinical veterinary and dental examine because it applies easy study to tissues in­ volved in daily defence opposed to microbes and opposed to environmental and meals antigens. This ebook is predicated at the contributions provided on the foreign Con­ gress of Mucosal Immunology, held in London in July 1989 and organised by means of the Mu­ cosal Immunology Affinity team of the British Society for Immunology. The meet­ ing used to be attended by means of over 500 delegates from 27 nations, together with almost all the major investigators within the box. The contents provide entire and up-to­ date details on such subject matters as antigen presentation and processing within the intestine, mucosal vaccines in guy and animals, HIV an infection within the intestine, the position of yo T cells within the intestine epithelium, fresh advances in inflammatory bowel affliction and coeliac dis­ ease, the position of cytokines within the rules of the IgA reaction, mucosal mast cells and cellphone migration. The contributions replicate the quick velocity of study in mucosal immunology, and the good strides that are occurring within the knowing of the immunology, molecular biology and biochemistry of host reaction at mucosal sur­ faces.

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Goodman, T. and Lefrancois, L. (1988) 'Expression of the y-o T-cell receptor on intestinal CD8+ intraepithelial lymphocytes', Nature 333, 855-858. 23. , Nakanishi, N. and Tonegawa, S. (1988) 'Intestinal intraepithelial lymphocytes are a distinct set of y-o T cells', Nature 336, 479-481. 24. , Jones, B. and Hayday, A. (1988) 'SpecifiCity and function of T cells bearing yo receptors', Immunol. Today 9, 73-76. 25. , Brandtzaeg, P. 'Intraepithelial T cells of the TcRylo+CD8- and VollJ ol+ phenotypes are increased in coeliac disease', Scand.

1. Introduction The secretory immunoglobulin (SIg) system is the best defined effector mechanism of mucosal immunity. It depends on cooperation between the local 8-cell system and the secretory epithelium which contribute, respectively, J chaincontaining polymeric Ig (pIgA and pIgM) and the epithelial pIg receptor called "secretory component" or SC [1]. , T cells and macrophages) and the secretory epithelium may upregulate the SC-dependent pIg transport as part of a local immune response [2]. Furthermore, lymphoepithelial interactions, perhaps involving the numerous intraepithelial lymphocytes (IEL) in 1 the gut, may participate in the modulation of mucosal immunity by normal downregulation and pathological upregulation of systemic types of immune responses to harmless luminal antigens [2,31.

Goodman, T. and Lefrancois, L. (1988) 'Expression of the y-o T-cell receptor on intestinal CD8+ intraepithelial lymphocytes', Nature 333, 855-858. 23. , Nakanishi, N. and Tonegawa, S. (1988) 'Intestinal intraepithelial lymphocytes are a distinct set of y-o T cells', Nature 336, 479-481. 24. , Jones, B. and Hayday, A. (1988) 'SpecifiCity and function of T cells bearing yo receptors', Immunol. Today 9, 73-76. 25. , Brandtzaeg, P. 'Intraepithelial T cells of the TcRylo+CD8- and VollJ ol+ phenotypes are increased in coeliac disease', Scand.

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