By Anders Olsen, Matthew S. Gill
This booklet brings jointly in a single quantity the present country of ageing learn within the nematode Caenorhabditis elegans. The authors are major researchers within the box, putting this subject within the context of human getting older, describing how and why easy discoveries during this basic organism have impacted our clients for intervention within the growing older strategy. The authors hide a extensive variety of themes just about organismal and reproductive growing older together with anatomical, physiological and biochemical alterations, in addition to genetic and environmental interventions that advertise toughness and ameliorate age-related affliction. growing older is the one most vital issue selecting the onset of human affliction in built nations. With present around the world demographic traits indicating that the variety of participants over the age of sixty five will proceed to upward thrust, it truly is transparent that an figuring out of the procedures that underpin getting older and age-related ailment represents a key problem within the biomedical sciences. in recent times there were large advances in our realizing of the getting older procedure and plenty of of those have stemmed from genetic research of C. elegans.
With no analogous booklet during this topic sector this paintings can be of curiosity to a large viewers, starting from educational researchers to the final public.
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Additional resources for Ageing: Lessons from C. elegans
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Pan CL, Peng CY, Chen CH, McIntire S (2011) Genetic analysis of age-dependent defects of the C. elegans touch receptor neurons. Proc Natl Acad Sci U S A 108(22):9274–9279. Morsci N, Hall DH, Driscoll M, Sheng ZH (2016) Age-related phasic patterns of mitochondrial maintenance in adult C. elegans neurons. J Neurosci 36(4):1373–1385. Tank EM, Rodgers KE, Kenyon C (2011) Spontaneous age-related neurite branching in C. elegans. J Neurosci 31(25):9279–9288. Gioran A, Nicotera P, Bano D (2014) Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway.
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