Download Aging and Age Related Ocular Diseases (Ophthalmologica, 1) by E. Lütjen-Drecoll PDF

By E. Lütjen-Drecoll

The phenomenon of getting older is characterised via a number of degenerative alterations, which differentially impact the hugely really good buildings in the eye, resembling the simply mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. for that reason, the attention can function an outstanding version approach to check age-related degenerative ailments. an outline article offers with the molecular biology of alpha-B-crystallin, and unique articles supply additional perception into the distribution and attainable sensible importance of nonlenticular alpha-B-crystallin. Retinal transplantation experiences that can finally bring about treatment for tapetoretinal degeneration and age-related macular degeneration are mentioned. additional, components that impression the improvement of the retinal tissues are investigated. And one other assessment examines cells of the deep lens fibers. This designated factor is an in-depth resource of data to ophthalmologists in learn and perform.

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Example text

23 Dahl D, Bignami A, Weber K, Osborne M: Filament proteins in rat optic nerves undergoing Wallerian degeneration: Localization of vimentin, the fibroblastic 100 Å filament protein in normal and reactive astrocytes. Exp Neurol 1981;73:496–506. 24 Dahl D, Strocchi P, Bignami A: Vimentin in the central nervous system: A study of the mesenchymal-type intermediate filament-protein in Wallerian degeneration and in postnatal rat development by two-dimensional gel electrophoresis. Differentiation 1982;22:185–190.

28 Kato S, Hirano A, Umahara T, Llena JF, Herz F, Ohama E: Ultrastructural and immunohistochemical studies on ballooned cortical neurons in Creutzfeldt-Jacob disease: Expression of alpha B-crystallin, ubiquitin and stress-response protein 27. Acta Neuropathol 1992;84: 443–448. 29 Renkawek K, deJong WW, Merck KB, Frenken CW, van Workum FP, Bosman GJ: Alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease. Acta Neuropathol (Berl) 1992;83:324–327. 30 Lütjen-Drecoll E, May CA, Polansky JR, Johnson DH, Bloemendal H, Nguyen TD: Localization of the stress protein ·B-crystallin and trabecular meshwork inducible glucocorticoid response protein in normal and glaucomatous trabecular meshwork.

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