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Sample text

Keshan Disease is characterized by cardiac enlargement, abnormal ECG patterns, cardiogenic shock, and congestive heart failure, with multifocal necrosis of the myocardium. The disease is reported to occur primarily in children and women of child-bearing age and has been successfully treated by selenium supplementation; however, a low incidence of cases persisting after selenium supplementation suggests that there may be other contributing factors. Kashin-Beck Disease is characterized by atrophy, degeneration, and necrosis of cartilage tissue, and occurs primarily in children between the ages of 5 and 13 years; it also has been successfully treated with selenium supplements.

Blind staggers has been repeatedly observed in cattle feeding off vegetation in areas with high selenium content ***DRAFT FOR PUBLIC COMMENT*** SELENIUM 2. RELEVANCE TO PUBLIC HEALTH in the soil. However, the neurological effects have not been replicated in experimentally-exposed cattle receiving doses of selenium sufficient to induce hoof lesions, and thus, the neurological symptoms associated with blind staggers may be due to other compounds found within this vegetation. Some evidence for adverse effects on the endocrine system has also been found following intermediate and chronic oral exposure to elevated levels of dietary selenium in humans and animals.

Animal studies support the respiratory system as the target of selenium toxicity, but these are acute studies of exposure to high concentrations of selenium that also produced serious health effects and death. Oral MRLs No MRLs were derived for acute or intermediate oral exposure to selenium because of insufficient quantitative data concerning both human and experimental animal exposures. For acute exposure, no ***DRAFT FOR PUBLIC COMMENT*** SELENIUM 2. RELEVANCE TO PUBLIC HEALTH quantitative data are available from studies of humans.

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