Download Antidiabetic Agents: Recent Advances in their Molecular and by H.P.T. Ammon, H.U. Häring, M. Kellerer, H. Laube, L. PDF

By H.P.T. Ammon, H.U. Häring, M. Kellerer, H. Laube, L. Mosthaf, E.J. Verspohl and M.A. Wahl (Eds.)

Quantity 27, the 1st thematic quantity within the sequence, presents an summary of current wisdom in regards to the pharmacological and medical facets of antidiabetic medicinal drugs. It goals to stimulate extra attention of attainable techniques within the improvement of latest antidiabetic medicines.

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Extra info for Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

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1991, 1992). , 1987). , 1991b). , 1991b). It is believed that this association leads to activation of PI 3-kinase which results in phosphorylation of phosphatidylinositol molecules (Cantley et al. , 1991). , 1993). Although some functional properties of IRS-1 have been defined, we can presume that not all of the functions of IRS-1 have been discovered. The role of IRS-1 is probably not restricted to its function as a docking protein for PI 3-kinase; it might rather play a multifunctional role as a signalling element for growth-promoting and metabolic effects.

Once symptomatic autonomic neuropathy is present the prognosis for survival is substantially diminished. The clinically silent phase of diabetic nephropathy in Type-II diabetes may last 5-10 years. It is characterized by rising urinary albumin excretion caused by a capillary lesion in the glomerulus. Microalbuminuria varies and can be found in 15-60% of all Type-II diabetics; it is defined by an excretion rate between 24 A N T I D I A B E T I C AGENTS 15 and 250p, gmin -l. In patients with microalbuminuria, coronary heart disease and proliferative retinopathy increase severalfold; without special care about 50% of the patients with persistent proteinuria will die within 7 years from uraemia, myocardial infarction or cerebral vascular accidents.

G. , 1990). 2 PHYSICAL EXERCISE Fuel homoeostasis and blood glucose levels are remarkably well maintained during physical exercise in healthy individuals. A decline in plasma insulin and an increase in glucagon are known to occur during intense and/or prolonged exercise. In diabetics, physical training improves glucose homoeostasis. e. normal insulin production, is absent. , 1988). , 1984). Thus, exercise in hyperinsulinaemic patients may result in hypoglycaemic reactions and, in hypoinsulinaemic diabetics, in increased blood glucose levels.

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