By M. Ian Phillips (auth.), M. Ian Phillips PhD, DSc (eds.)
Announcement of the entire sequencing of the human genome in April 2003 confirmed the presence of millions of objectives for antisense oligonucleotides and opened the best way to hundreds and hundreds of preclinical animal stories and a few 20 ongoing medical trials. during this moment version of Antisense Therapeutics, a crew of top researchers and scientific scientists display the hot fact of antisense and RNA inhibition for treating a huge diversity of ailments. The authors express how antisense oligonucleotides are being designed and studied relating to high blood pressure, quite a few cancers, inflammatory bowel disorder, mind problems, the blood-brain barrier, and drug supply. Highlights contain RNA-based cures for lots of ailments, up to date equipment and functions, and perception into the large strength to supply a brand new iteration of substances.
hugely sensible and disorder orientated, Antisense Therapeutics, moment variation deals not just a primer for a brand new new release of drug discovery researchers, but additionally an illuminating exploration of the capability in exploiting RNA inhibition for novel human therapeutics.
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Additional info for Antisense Therapeutics
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The studies demonstrate a remarkable agreement of inhibition of MYC with a resident amount of AVI-4126 in the vessel wall. Table 6 reveals an excellent agreement between the published IC50 of 300 nM for Resten-NG in inhibiting MYC (6) and the observed (IC61) at the 415 nM in the high-dose group. Inhibition by the low-dose stent was essentially equal to the high-dose stent, and the concentration at 24 h was is somewhat less but still in reasonable agreement given the difference between cell culture and in vivo blood vessels.
R. (2001) Application of PNA and LNA oligomers to chemotherapy. Curr. Opin. Investig. Drugs 2, 558–561. 12. , Read, R. , and Van Meervelt, L. (2002) Crystal structure of double helical hexitol nucleic acids. J. Am. Chem. Soc. 124, 928–933. Antisense Inhibition 29 13. , and Zhang, R. (2002) Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: in vivo activity and mechanisms. Int. J. Oncol.
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