By Richard A. Kahn
For the 1st time specialists within the quarter of signalling learn with a spotlight at the ARF kinfolk have contributed to the creation of a name dedicated to ARF biology. A complete phylogenetic research of the ARF kinfolk, tables of the ARF GEFs and ARF GAPs, and greater than a dozen chapters describing them intimately are supplied. The effect of the ARF proteins on greatly varied points of telephone biology and telephone signalling will be truly visible from the actions defined; together with membrane site visitors, lipid metabolism, receptor desensitization, mouse improvement, microtubule dynamics, and bacterial pathogenesis. a person attracted to knowing the complexities of cellphone signalling and the mixing of signalling networks will make the most of this quantity.
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Additional resources for ARF Family GTPases (Proteins and Cell Regulation)
G. (1995). ARP is a plasma membraneassociated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors. J. Biol. , 270, 30657-30663. Sewell, J. , and Kahn, R. A. (1988). Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc. Natl. Acad. , USA, 85, 4620-4624. Sharer, J. , and Kahn, R. A. (1999). The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. J. Biol. , 274, 27553-27561.
The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Dev Cell, 2, 579-591. , and Schekman, R. (1993). Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum. J. Biol. , 268, 873-879. , Lewis, S. , and Cowan, N. J. (2000). ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.
1988). Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc. Natl. Acad. , USA, 85, 4620-4624. Sharer, J. , and Kahn, R. A. (1999). The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. J. Biol. , 274, 27553-27561. Sharer, J. , Shern, J. , Wallace, D. , and Kahn, R. A. (2001). ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter (ANT). Mol. Biol. Cell, 2002, 71-83. Tamkun, J.
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