By Elisabeth Hsu (auth.), Tariq Aftab, Jorge F.S. Ferreira, M. Masroor A. Khan, M. Naeem (eds.)
Artemisinin, a sesquiterpene lactone initially extracted from the medicinal plant Artemisia annua L., is a good antimalarial agent, rather for multi-drug resistant and cerebral malaria. in spite of the fact that, the focus of artemisinin within the plant is particularly low. as the chemical synthesis of artemisinin is advanced and never economically possible in view of the terrible yield of the drug, the intact plant continues to be the one achievable resource of artemisinin construction. consequently, it's important to extend the focus of artemisinin in A. annua to lessen the price of artemisinin dependent antimalarial medications. Plant scientists have targeted their efforts on A. annua for a better artemisinin crop yield. With the current quantity, we're bringing jointly the learn that is being performed in this plant during the global and destiny chances for scientists and researchers who are looking to paintings on it.
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This quantity is meant for clinicians, researchers, citizens, and scholars. the variety is broad and the intensity significant for all of the themes lined within the therapy of this well timed and suitable topic. This booklet may possibly serve both good as a common advent and a scholarly reference. finally, it really is designed to serve these sufferers being affected by abuse of and dependancy to medications and alcohol.
Artemisinin, a sesquiterpene lactone initially extracted from the medicinal plant Artemisia annua L. , is a good antimalarial agent, relatively for multi-drug resistant and cerebral malaria. in spite of the fact that, the focus of artemisinin within the plant is especially low. as the chemical synthesis of artemisinin is complex and never economically possible in view of the terrible yield of the drug, the intact plant is still the single achievable resource of artemisinin creation.
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Additional info for Artemisia annua - Pharmacology and Biotechnology
5 Falciparum Aqueous infusion 20 5 93 (%) 13 % 254 Falciparum ? others Aqueous infusion 35 7 92 (%) ? 48 Aqueous 20 decoction 4 a N = Number of subjects Source Wilcox et al. 2004a, b Falciparum Chang and But (1986) Chang and But (1986) Yao-De et al. (1992) Mueller et al. (2000) Hirt and Lindsey (2000) Mueller et al. 3 Clinical data of 48 malaria patients before and after treatment with A. annua teaa Before treatment After treatment Parasitaemia (P. falciparum) Subjective symptoms Among these Headache Fever Chills Arthralgia Vertigo Others 48 (100 %) 48 (100 %) 4 (8 %) 11 (23 %) 37 27 10 14 6 27 3 1 0 4 1 8 a Eighteen men, 30 women; mean age 38 years, range 18–67 years Source Mueller et al.
2001; and Ro et al. 2006), but not much success has been achieved because of the high cost of chemical synthesis procedure or complex nature of regulation and expression of the genes responsible for artemisinin biosynthesis (Fig. 1). 2 Artemisia annua: An Antimalarial Herbal Drug Artemisia annua, known with different names such as sweet wormwood, sweet annie, qinghao and annual wormwood, is a native shrub of China, where it has long been used both ornamentally and for medicinal purposes (Duke et al.
PLoS ONE 4(2):e4551 Carrington A (2001) Malaria: Its human impact, challenges, and control strategies in Nigeria. Harvard Health Public Rev 2:54–60 University Hall, Cambridge, Massachusetts 3 Artemisia annua: A Miraculous Herb to Cure Malaria 47 Chang HM, But PPH (1986) Pharmacology and applications of Chinese materia media, vol 1. World Scientific Publishing, Singapore Charles DJ, Simon JE, Wood KV, Heinstein P (1990) Germplasm variation in artemisinin content of Artemisia annua using an alternate method of artemisinin analysis from crude plant extracts.
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