Download Atherosclerosis, Large Arteries and Cardiovascular Disease by M.E. Safar, E.D. Frohlich, J.S. Borer PDF

By M.E. Safar, E.D. Frohlich, J.S. Borer

Arterial stiffness is now firmly tested as a big and self sustaining predictor of cardiovascular hazard. The structural and practical alterations of the big arteries will be age-related, yet a few stipulations were linked to speeded up arterial stiffening together with the hypertensive ailments, atherosclerosis, end-stage renal disorder, and standard cardiovascular possibility components akin to diabetes mellitus and smoking. This e-book offers the present deliberating overseas specialists concerning the underlying mechanisms of cardiovascular hazard, and the pathogenesis and pathophysiology of huge arterial stiffness and diminished huge arterial distensibility. It not just supplies new insights into the connection among arterial stiffness and atherosclerosis, but in addition establishes the prospective interactions with age and different cardiovascular elements equivalent to hypertension, diabetes and hyperlipidemia. eventually, the healing technique of forthcoming arterial stiffness are analyzed intimately and new views for the remedy and prevention of cardiovascular illnesses are constructed. Authoritative and updated, this ebook is a worthy source for uncomplicated scientists attracted to vascular body structure and pathophysiology, for clinicians within the parts of cardiology, diabetes and renal illnesses, in addition to for investigators in drug improvement.

Show description

Read or Download Atherosclerosis, Large Arteries and Cardiovascular Disease PDF

Best geriatrics books

Dysphagia: Diagnosis and Treatment

This publication presents a entire and up to date description of the analysis and administration of dysphagia, with specific connection with oral and pharyngeal disorder. All elements of dysphagia are coated, from anatomy and body structure to sufferer care. along descriptions of quite a few disorder entities, symptoms, and remedy ways, many different suitable themes are addressed, together with endoscopic and manometric facets, malnutrition and dehydration, the psychiatric burden, and lines particular to pediatric and geriatric sufferers.

Aging and Human Motivation

I first met Ernest Furchtgott twenty-five years in the past after becoming a member of the college of the school of Social paintings on the college of South Carolina. at the moment, Ernie chaired the dept of Psychology. within the following 3 years we collaborated with a tutorial Committee on Gerontology in conceptualizing and shaping the University's certificates of Graduate examine in Gerontology application, guiding it to ultimate approval by way of the South Carolina fee on larger schooling.

Movement Disorders in Dementias

This ebook specializes in extrapyramidal symptoms of all kinds of dementia, and addresses the problem of the synthetic boundary among dementias and Parkinsonism, which signify the 2 commonest indicators present in degenerative vital anxious procedure ailments. In move issues in Dementias, circulation illness experts from around the globe write on issues commonly limited to dementia specialists.

Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants

This leading edge reference explores a big variety of themes linked to getting older, delivering an effective knowing of the importance and molecular foundation of the getting older approach and charting the process destiny learn within the sector. Stresses the interaction of mitochondria, mitochondrial DNA, oxidants, and antioxidants!

Additional resources for Atherosclerosis, Large Arteries and Cardiovascular Disease

Example text

Arterioscler Thromb Vasc Biol 2004;24:782–786. Mitchell GF, Izzo JL Jr, Lacourciere Y, Ouellet JP, Neutel J, Qian C, Kerwin LJ, Block AJ, Pfeffer MA: Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study. Circulation 2002;105:2955–2961. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG: Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.

Circulation 2001;104:1464–1470. Van Bortel LM, Spek JJ: Influence of aging on arterial compliance. J Hum Hypertens 1998; 12: 583–586. Kelly R, Hayward C, Avolio A, O’Rourke M: Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989;80:1652–1659. O’Rourke MF, Nichols WW: Changes in wave reflection with advancing age in normal subjects. Hypertension 2004;44:e10. O’Rourke MF, Nichols WW: Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension.

Arterial Changes in Aging and Hypertension Arteriosclerosis is the process of age-related large artery stiffening usually found in individuals with wide PP or systolic hypertension. This adventitial and medial process must be differentiated from atherosclerosis, the occlusive low-grade endovascular inflammatory process that results from endothelial dysfunction and lipid oxidation. Arteriosclerosis often coexists with atherosclerosis but is worth differentiating from the former because prevention and treatment of the two conditions probably differ significantly.

Download PDF sample

Rated 4.99 of 5 – based on 31 votes