By M.E. Safar, E.D. Frohlich, J.S. Borer
Arterial stiffness is now firmly tested as a big and self sustaining predictor of cardiovascular hazard. The structural and practical alterations of the big arteries will be age-related, yet a few stipulations were linked to speeded up arterial stiffening together with the hypertensive ailments, atherosclerosis, end-stage renal disorder, and standard cardiovascular possibility components akin to diabetes mellitus and smoking. This e-book offers the present deliberating overseas specialists concerning the underlying mechanisms of cardiovascular hazard, and the pathogenesis and pathophysiology of huge arterial stiffness and diminished huge arterial distensibility. It not just supplies new insights into the connection among arterial stiffness and atherosclerosis, but in addition establishes the prospective interactions with age and different cardiovascular elements equivalent to hypertension, diabetes and hyperlipidemia. eventually, the healing technique of forthcoming arterial stiffness are analyzed intimately and new views for the remedy and prevention of cardiovascular illnesses are constructed. Authoritative and updated, this ebook is a worthy source for uncomplicated scientists attracted to vascular body structure and pathophysiology, for clinicians within the parts of cardiology, diabetes and renal illnesses, in addition to for investigators in drug improvement.
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Additional resources for Atherosclerosis, Large Arteries and Cardiovascular Disease
Arterioscler Thromb Vasc Biol 2004;24:782–786. Mitchell GF, Izzo JL Jr, Lacourciere Y, Ouellet JP, Neutel J, Qian C, Kerwin LJ, Block AJ, Pfeffer MA: Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study. Circulation 2002;105:2955–2961. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG: Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.
Circulation 2001;104:1464–1470. Van Bortel LM, Spek JJ: Influence of aging on arterial compliance. J Hum Hypertens 1998; 12: 583–586. Kelly R, Hayward C, Avolio A, O’Rourke M: Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989;80:1652–1659. O’Rourke MF, Nichols WW: Changes in wave reflection with advancing age in normal subjects. Hypertension 2004;44:e10. O’Rourke MF, Nichols WW: Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension.
Arterial Changes in Aging and Hypertension Arteriosclerosis is the process of age-related large artery stiffening usually found in individuals with wide PP or systolic hypertension. This adventitial and medial process must be differentiated from atherosclerosis, the occlusive low-grade endovascular inflammatory process that results from endothelial dysfunction and lipid oxidation. Arteriosclerosis often coexists with atherosclerosis but is worth differentiating from the former because prevention and treatment of the two conditions probably differ significantly.
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