Download Biochemical Pharmacology as an Approach to Gastrointestinal by K. D. Rainsford (auth.), Timothy S. Gaginella, Gyula Mózsik, PDF

By K. D. Rainsford (auth.), Timothy S. Gaginella, Gyula Mózsik, K. D. Rainsford (eds.)

The Gastrointestinal portion of the overseas Union of Pharmacology (IUPHAR) was once verified in 1994 in Montreal, Canada. The institution of the GI part acknowledges the foreign growth of gastrointestinal pharmacology, together with simple and human reviews.
The Gastrointestinal portion of IUPHAR geared up the 1st symposium, Biochemical Pharmacology as an method of Gastrointestinal illnesses: from simple technological know-how to medical Perspectives, on 10-12 October, 1995, in Pécs, Hungary.
the most issues were:

  • Gastrointestinal secretory and excretory fuctions
  • Gastrointestinal motility
  • Biochemical-pharmacological mechanisms in neural and hormonal activities serious about GI capabilities
  • major basic and pathological biochemical mechanisms in GI features
  • GI mucosal damage and defense
  • Molecular mechanisms of premalignant and malignant ailments in GI tract
  • Use of remoted cells and mobile cultures in bioochemical-pharmacological reports to strategy GI ailments.

The offered papers are released during this ebook.

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Extra resources for Biochemical Pharmacology as an Approach to Gastrointestinal Disorders: Basic Science to Clinical Perspectives (1996)

Sample text

The stimulatory pathway is dependent on histamine which may be released from mucosal mast cells in association with capsaicin-sensitive sensory nerves; and 3. L-NAME unmasks the acid-stimulatory response by suppressing the inhibitory pathway. Keywords: stomach, barrier disruption, taurocholate, acid secretion, nitric oxide, histamine, sensory neuron INTRODUCTION The application of a mucosal-damaging agent to the stomach has been shown to cause a luminal alkalinization, mainly by the inhibition of acid secretion [1-3].

That gastrin accelerates several of the steps that control the birth and subsequent maturation of storage/secretory organelles, namely the formation of granules, their transformation into secretory vesicles, exocytosis and endocytosis (resulting in microvesicles), and the fusion of several secretory vesicles with each other (resulting in vacuoles) (Figure 13). CONCLUSIONS 1. Secretory vesicles in ECL cells develop from granules and represent a major storage site for histamine. 2. Granules develop into secretory vesicles, partly as a result of accumulation of histamine from the cytoplasm.

Secretory Pathways in Histamine-Containing Enterochromaffin-Like Cells of Rat Stomach 55 7. Nissinen M, Panula P. Histamine-storing cells in the oxyntic mucosa of the rat stomach: A transmission electron microscopic study employing fixation with carbodiimide. 1. Histochem Cytochem. 1993;41 :1405-12. 8. Kahlson G, Rosengren E, Svensson SE. Histamine and gastric acid secretion with special reference to the rat. In: Holton P, ed. Pharmacology of Gastrointestinal Mobility and Secretion. 1. Oxford: Pergamon; 1973:41-101.

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