By James R. Swearengen
The significance hooked up to quickly constructing our biodefensive functions has lately led to a considerably elevated investment for biodefense examine. hence, researchers will reply with an attempt equivalent to the problem, generating a powerful physique of findings.
To make sure that this attempt keeps within the most productive demeanour, Biodefense: study method and Animal versions provides an intensive old and present overview of biodefense study, encouraging researchers to leverage appropriate effects, instead of reproduction them. via development at the paintings of others, scientists should be in a position to continue in a manner that makes the easiest use of accessible assets, whereas averting pointless duplication of animal study.
Including contributions from well-known leaders within the box who've constructed and sophisticated the animal types offered, this e-book examines these bacterial, viral, and poisonous brokers thought of to pose the best threats to public security. each one part on a particular agent presents pertinent history details, by means of an outline of these animal versions hired in study and checking out and a dialogue of ways the findings translate to human effect.
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Additional info for Biodefense: Research Methodology and Animal Models
3. , Pox Americana. The Great Smallpox Epidemic of 1775–82. Hill and Wang, New York, 2001. 4. , The historical development and relative value of laboratory and clinical methods in diagnosis. The evolution of the idea of experiment in medicine, in Transactions of the Congress of American Physicians and Surgeons, 1907, Volume 7, 1–8. 5. Osler, W. The evolution of modern medicine, the rise of preventive medicine. A series of lectures delivered at Yale University on the Silliman Foundation in April 1913.
The negative outcomes of variolation and the need to provide continuous and sustainable progress in providing the means to protect the health and safety of soldiers in any future battlefield in all likelihood led Congress to create the Army Medical Department in the spring of 1818. The story about the discoverers of mosquito transmission of yellow fever is important to describe because it is a milestone leading up to the need for using animals to prove efficacy of medical countermeasures against serious biological hazards [4–6].
These discussions can provide useful insight into the applicability and limitations of the animal efficacy rule. In conclusion, the animal efficacy rule should be used for product approval only when it is clear that conducting research trials to find substantial evidence of human clinical efficacy would be unethical or immoral. This is the only appropriate justification because the justification for this rule is not lessening the standards of product approval. Rather, the justification is to allow approval of medical countermeasures where it would be extremely dangerous to test for efficacy in humans.
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