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By E. Boden

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Sample text

Continuous low-level administration of antibiotics has been shown to increase the incidence of resistant organisms. The emergence of resistant strains of salmonella in calves receiving in-feed antibiotics has been of concern. As long ago as 1972, a MAFF study of 2166 strains of salmonella isolated from farm animals found that 90 per cent were resistant to streptomycin. There has been concern that the use of antibiotics as growth promoters could encourage development of resistant organisms. Consequently, antibiotics used in this way should be selected from those not used therapeutically in animals or humans.

Their walls are composed of 3 coats: (1) adventitious coat, consisting of ordinary strong fibrous tissue on the outside; (2) middle coat, composed of muscle fibres and elastic fibres, in separate layers in the great arteries; (3) inner coat or intima, consisting of a layer of yellow elastic tissue on whose innermost surface rests a single continuous layer of smooth, plate-like endothelial cells, within which flows the bloodstream. The walls of the larger arteries have the muscles of their middle coat replaced to a great extent by elastic fibres so that they are capable of much distension.

It is characterised by acute anaemia, fever, jaundice, and degeneration of the internal organs; haemoglobinuria does not occur as the rate of red-bloodcell destruction is not fast enough to produce free haemoglobin in the circulating blood. Young animals appear to be resistant, and cases in calves under 1 year old are rare. In older animals the disease may be acute or chronic, and in the former case they may die within 2 to 3 days after the appearance of the first symptoms. 5°C (105° to 107°F) and after a day or two anaemia and icterus appear.

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