Download Caloric restriction: a key to understanding and modulating by E. J. Masoro PDF

By E. J. Masoro

For a few years, it's been identified that once rats and mice are given a discounted quantity of meals, their lifestyles span is elevated and so they stay fit and full of life at complicated ages.

what's the cause of this transformation within the traditional trend of getting older? The proof is overwhelming that the lifestyles extension effects from a slowing of getting older strategies. And the issue dependable is the reduce in caloric consumption. the most obvious query: How does this issue paintings? an outstanding query - and the explanation that examine at the anti-aging motion of caloric restrict is this present day probably the most studied learn components in organic gerontology. For it truly is felt that if the organic mechanisms of the anti-aging motion of caloric restrict might be exposed, we'd achieve an realizing of the fundamental nature of getting older techniques, which might, in flip, yield attainable interventions in human getting older. This ebook goals to supply the becoming variety of researchers during this box (faculty, postdoctoral trainees, and graduate scholars) with a close wisdom of what's recognized approximately caloric restrict in the body of gerontology, in addition to insights on way forward for this box.

Show description

Read or Download Caloric restriction: a key to understanding and modulating aging PDF

Similar geriatrics books

Dysphagia: Diagnosis and Treatment

This e-book offers a accomplished and updated description of the prognosis and administration of dysphagia, with specific connection with oral and pharyngeal disorder. All elements of dysphagia are lined, from anatomy and body structure to sufferer care. along descriptions of various sickness entities, signs, and remedy techniques, many different suitable subject matters are addressed, together with endoscopic and manometric facets, malnutrition and dehydration, the psychiatric burden, and lines particular to pediatric and geriatric sufferers.

Aging and Human Motivation

I first met Ernest Furchtgott twenty-five years in the past after becoming a member of the college of the school of Social paintings on the college of South Carolina. at the moment, Ernie chaired the dep. of Psychology. within the following 3 years we collaborated with a tutorial Committee on Gerontology in conceptualizing and shaping the University's certificates of Graduate research in Gerontology software, guiding it to ultimate approval by means of the South Carolina fee on better schooling.

Movement Disorders in Dementias

This e-book specializes in extrapyramidal symptoms of all kinds of dementia, and addresses the problem of the synthetic boundary among dementias and Parkinsonism, which symbolize the 2 commonest indicators present in degenerative critical worried method ailments. In move issues in Dementias, stream affliction experts from world wide write on themes commonly limited to dementia specialists.

Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants

This leading edge reference explores a big variety of issues linked to getting older, offering an outstanding figuring out of the importance and molecular foundation of the getting older technique and charting the process destiny examine within the sector. Stresses the interaction of mitochondria, mitochondrial DNA, oxidants, and antioxidants!

Extra resources for Caloric restriction: a key to understanding and modulating aging

Example text

It also decreases both growth hormone-induced activation and nuclear translocation of Stat-3 (Xu & Sonntag, 1996b). , 1993). Indeed, CR has been found to modulate age-associated changes in cellular signaling in several other tissues. , 1997). , 1983). Scarpace and Yu (1987) found that CR retards the ageassociated loss of beta-adrenergic receptors in rat lung; it also prevents the age-associated decrease in isoproterenol- and epinephrine-stimulated adenylate cyclase activity in this organ. With age, the activation by concanavalin A of two important components of cellular signaling pathways, MAPK and calcineurin, decreases in rat splenic T cells, and this is partially prevented by CR (Pahlavani & Vargas, 2000).

21 23 28 31 31 36 38 40 41 Any intervention that slows the aging processes probably does so by affecting fundamental molecular and cellular functions. CR influences many cellular processes, causing some functions to change almost immediately and slowing age-associated changes in others. One or more of these cellular and/or molecular effects is (are) likely to play key roles in CR’s anti-aging and life-extending actions. Stability of the nuclear genome It has long been theorized that nuclear genomic instability is the basis of senescence (Failla, 1958; Szilard, 1959).

1994a). , 1994a). Based on the hypoxanthine phosphoribosyl 21 RESEARCH PROFILES IN AGING VOLUME 1 ISSN 1567-7184 COPYRIGHT ß 2002 ELSEVIER SCIENCE LTD ALL RIGHTS RESERVED 22 Caloric Restriction: A Key to Understanding and Modulating Aging Figure 3-1. Effect of age on 8-OHdG content of the DNA in the tissues of male C57BL/6 mice and CR’s ability to decrease its content. The open bars denote the difference in content between 8 and 27 month old mice. The hatched bars denote the decreased content in the tissues of 15-month-old mice that have been on longterm CR compared to mice of the same age on an ad libitum diet.

Download PDF sample

Rated 4.20 of 5 – based on 5 votes