By G. Turitto (auth.), Antonio Raviele MD (eds.)
The topic of cardiac arrhythmias is of functional relevance. numerous arrhythmias are present in diverse medical events, akin to untimely complexes in fit members, supraventricular tachyarrhythmias in sufferers with Wolff-Parkinson-White snydrome, atrioventricular block, and ventricular traumatic inflammation in cardiopathic stipulations, in particular in sufferers with ischemic affliction. subject matters of significant curiosity are mentioned during this quantity: malignant ventricular arrhythmias, unexpected demise, computerized implantable cardioverter defibrillators, syncope, present symptoms for pacing treatment, radiofrequency catheter ablation, flutter, and atrial fibrillation.
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Extra resources for Cardiac Arrhythmias 1995: Proceedings of the 4th International Workshop on Cardiac Arrhythmias (Venice, 6–8 October 1995)
Furthermore, the fact that sotalol was not as effective as class I drugs (such as mexiletine) in suppressing nonsustained VT on Holter recordings but reduced mortality to a greater extent than did class I agents emphasizes again the dichotomy between arrhythmia suppression and total mortality. The fact that the techniques did not differ in predicting the outcome of drug therapy based on acute responses but the two classes of drugs did differ in this regard emphasizes drug-specific rather than technique-specific responses as the crucial determinants of the outcomes of pharmacologic therapy of VTIVF (2, 4-6).
The fact that the techniques did not differ in predicting the outcome of drug therapy based on acute responses but the two classes of drugs did differ in this regard emphasizes drug-specific rather than technique-specific responses as the crucial determinants of the outcomes of pharmacologic therapy of VTIVF (2, 4-6). This is further supported by the results of the CASCADE Trial (28) in which survivors of cardiac arrest were randomized to Holter or PES-guided therapy involving class I agents versus amiodarone.
The reasons for the apparently marked difference between the mortality outcomes in CHF STAT and those in GESICA remain unclear. However, besides the blinded nature of CHF STAT, the most striking difference is the smaller proportion (39%) of the patients in OESICA who had coronary artery disease compared to that (70%) in the CHF STAT. 07). Whether this is the sole explanation for the differences in mortality between the two studies is uncertain. In this regard, the CHF STAT data on amiodarone, a powerful anti adrenergic agent with long-lasting effects (36), are similar to those of chronic beta-blockade with bisopropol in cardiac failure in 641 patients revealing no significant effect on total mortality (37).
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