Download Ciba Foundation Symposium 106 - Human Cataract Formation PDF

Chapter 1 advent (pages 1–2): A. Spector
Chapter 2 class of Human Cataractous swap by way of the yank Cooperative Cataract learn workforce technique (pages 3–24): Leo T. Chylack
Chapter three Epidemiological and different stories within the overview of things Contributing to Cataractogenesis (pages 25–47): R. M. Clayton, J. Cuthbert, J. Seth, C. I. Phillips, R. S. Bartholomew and J. Mck. Reid
Chapter four Oxidation and Cataract (pages 48–64): Abraham Spector
Chapter five Metabolism and serve as of Glutathione within the Lens (pages 65–87): Venkatn. Reddy and Frank J. Giblin
Chapter 6 Cataracts and Photochemical harm within the Lens (pages 88–109): Raymond F Borkman
Chapter 7 Diabetic and Galactosaemic Cataracts (pages 110–131): Peter F. Kador and Jin H. Kinoshita
Chapter eight Calcium and the body structure of Cataract (pages 132–162): George Duncan and Tim J. C. Jacob
Chapter nine Cytoskeletal Proteins of the getting old Human Lens (pages 163–176): Harry Maisel
Chapter 10 interplay of Crystallins with the Cytoskeletal–Plasma Membrane advanced of the Bovine Lens (pages 177–190): Hans Bloemendal, Wilfried W. De Jong, Frans C. S. Ramaekers, Alphons J. M. Vermorken, Irene Dunia and E. Lucio Benedetti
Chapter eleven Crystallin Genes: Templates for Lens Transparency (pages 191–207): Joram Piatigorsky, John M. Nickerson, Charles R. King, George Inana, J. Fielding Hejtmancik, James W. Hawkins, Teresa Borras, Toshimichi Shinohara, Graeme Wistow and Barbara Norman
Chapter 12 The Crystallin Gene households (pages 208–217): John G. G. Schoenmakers, Johan T. Den Dunnen, Rob J. M. Moormann, Rosalie Jongbloed, Rob W. Van Leen and Nicolette H. Lubsen
Chapter thirteen The Molecular buildings and Interactions of Bovine and Human ??Crystallins (pages 219–236): Lesley Summers, Christine Slingsby, Helen White, Michael Narebor, David Moss, Linda Miller, Daruka Mahadevan, Peter Lindley, Huub Driessen, Tom Blundell, Johan Den Dunnen, Rob Moormann, Rob Van Leen and John Schoenmakers
Chapter 14 The Molecular foundation of Cataract Formation (pages 237–247): George B. Benedek
Chapter 15 Non?Invasive innovations within the examine of Cataract improvement on the Metabolic and Protein Molecular point (pages 248–274): William H. Garner

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Extra resources for Ciba Foundation Symposium 106 - Human Cataract Formation

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Benedek: In diabetics, cataracts are extracted at an earlier age than in non-diabetics, so the inference is that they are more advanced and develop earlier, but that has not been proved. In the Framingham study there was an association between raised blood sugar concentration and cataract, but there is little more epidemiological evidence than that. Clayton: This has also emerged from the HANES and Edinburgh studies. Horwitz: Is there any special feature in the morphology of the diabetic cataract which we know from experimental models?

There may also be a genetic component in the relationship between cataract and alcohol. Drews (1970) and Sabiston (1973) found presenile cataracts in alcoholics, and we found an association with relatively heavy drinking; but genetic differences in the rate of metabolism and even in preference are well known in mouse and man. All this is still hypothetical as regards human cataract. However, there is evidence for genetic differences between rat strains in the cataractogenic effects of naphthalene (see Koch et al 1976).

Explain polygenically determined phenotypes, and this concept has been proposed for cataract formation by Hockwin & Koch (1975). Our evidence (Fig. 3) supports this hypothesis. The mean values in the cataract population for several plasma components deviate from the means of the non-cataract population (see Table 1) in the direction in which, for many of them, cataractogenic potential lies, but these deviations were not associated with any well-defined pathology, and each may be due to several factors.

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