Download Comparative Biology of Aging by Norman S. Wolf PDF

By Norman S. Wolf

Made up our minds through an lack of ability to maneuver in accordance with contact. C. elegans enhance via 4 larval phases following hatching and ahead of maturity. grownup C. elegans are reproductive for approximately the rst week of maturity through nearly weeks of post-reproductive maturity sooner than loss of life. existence span is most typically measured within the laboratory by way of keeping the worms at the floor of a nutrie- agar medium (Nematode progress Medium, NGM) with E. coli OP50 because the bacterial foodstuff resource (REF). substitute tradition stipulations were defined in liquid media; even though, those will not be known for toughness stories. sturdiness of the generally used wild variety C. elegans hermaphrodite (N2) varies ? from sixteen to 23 days below ordinary laboratory stipulations (20 C, NGM agar, E. coli OP50 foodstuff source). existence span should be elevated via conserving animals at decrease ambient temperatures and shortened by means of elevating the ambient temperature. Use of a killed bacterial nutrients resource, instead of reside E. coli, raises lifespan via 2–4 days, and development of grownup animals within the absence of micro organism (axenic progress or bac- rial deprivation) raises median lifestyles span to 32–38 days [3, 23, 24]. lower than either normal laboratory stipulations and bacterial deprivation stipulations, wild-derived C. elegans hermaphrodites convey toughness akin to N2 animals [25]

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98. Fenton M and Barclay R (1980). Myotis lucifugus. Mammalian Species 142: 1–8. S. Wolf and S. Austad 99. Davis WH and Hitchcock HB (1995). A new longevity record for the bat Myotis lucifugus. Bat Research News 36: 6. 100. Brunet-Rossinni AK (2004). Reduced free-radical production and extreme longevity in the little brown bat (Myotis lucifugus) versus two non-flying mammals. Mech Ageing Dev 125: 11–20. 101. Holmes DJ, Fluckiger R, and Austad SN (2001). Comparative biology of aging in birds: An update.

Nature 366(6465): 461–464. 36. Klass MR (1977). Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span. Mech Ageing Dev 6(6): 413–429. 37. Garigan D et al. (2002). Genetic analysis of tissue aging in Caenorhabditis elegans: A role for heat-shock factor and bacterial proliferation. Genetics 161(3): 1101–1112. 38. Garsin DA et al. (2003). Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300(5627): 1921. 39. Bauer JH, Goupil S, Garber GB, and Helfand SL (2004).

Another study simply documented the ages at which older horses versus ponies were brought to a large teaching hospital for veterinary clinical evaluation. Whereas ponies formed only 13% of animals evaluated at ages 20–29 years, they formed nearly half of animals seen at ages thirty years or older [49]. A surprising phenomenon which may or may not be linked with aging is that young ponies are also known to have substantially faster wound healing than horses. Specifically, a standardized surgical wound had healed in all five experimental ponies by 7–9 weeks whereas it was 12 weeks before the first (of 5) horse’s wound had healed [50, 51].

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