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By Martine Extermann MD, Lodovico Balducci, William B. Ershler, Gary H. Lyman, Martine Extermann

The prevention and therapy of melanoma in older sufferers calls for an individualized procedure, as age explanations unpredictable effects from sufferer to sufferer. thoroughly revised and up-to-date, this moment version of a bestseller allows clinicians to decide on the absolute best melanoma care. Highlighting rising concerns in geriatric oncology, it is helping physicians advertise melanoma prevention and exhaustively stories the biology of melanoma and getting older, epidemiologic tendencies, and scientific trials. New chapters include fabric on issues reminiscent of review, fragility, symptom administration, and emergencies, and stories of the effectiveness of teaching courses in geriatric oncology.

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24. Rosenberg SA. Non-Hodgkin’s lymphoma—selection of treatment on the basis of histologic type. N Engl J Med 1979; 301:924–8. 25. Lichtman SM. Lymphoma in the older patient. Semin Oncol 1995; 22(Suppl 1): 25–8. 26. Hosking MP, Warner MA, Lobdell CM et al. Outcomes of surgery in patients 90 years of age and older. JAMA 1989; 261:1909–15. 27. Trimble EL, Carter CL, Cain D et al. Representation of older patients in cancer treatment trials. Cancer 1994; 74:2209–14. 28. Hutchins LF, Unger JM, Crowley JJ et al.

2 illustrates a hypothetical decision model or tree for two therapeutic alternatives with uncertainty about the diagnosis of disease. 2(a), the outcome for each treatment/disease pathway is represented as a utility. The benefit of treatment by convention is represented by the difference among treated and untreated individuals with the disease, while the harm or risk of treatment is the difference among treated and untreated individuals without the disease. 2c). Once baseline probabilities and outcome values have been assigned, each node can be evaluated by multiplying the outcome value by the probability of each branch and adding the products of the branches from each node together.

28. Hutchins LF, Unger JM, Crowley JJ et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341:2061–7. 29. Kennedy BJ, Calabresi P, Carbone P et al. Training program in medial oncology. Ann Intern Med 1973; 78:127–30. 30. Kennedy BJ. The origin and evolution of Medical Oncology. Lancet 1999; 354(Suppl): 41. Aging and cancer 17 31. Kennedy BJ. Aging and cancer. Oncology 2000; 14:1731–40. 1 Medical knowledge may be derived from personal experience as well as systematic research.

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