By J. Murdoch Ritchie, Pierre J. Magistretti and Liana Bolis (Eds.)
A severe consider cell-to-cell interactions is the presence within the mobile membrane of hugely particular ion channels managed through particular receptors which are sure to, and activated via, a gamut of exterior hormones and neurotransmitters. via either this motion on ion channels, and motion on different membrane parts (such as G-proteins), extracellular signs adjust intracellular occasions, frequently throughout the mediation of moment messengers, and so give you the foundation for the transduction mechanism connecting extracellular indications with intracellular effectors. This quantity offers with a few of the ways in which such membrane functionality is managed
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Extra info for Control of membrane function: Short-term and long-term
A possible involvement of cyclic A M P in the expression of desensitization of the nicotinic acetylcholine receptor: a study with forskolin and its analogs. FEBS Lett 199: 1 1 3 - 1 2 0 . Changeux J-P, Devillers-Thiery A , Chemouilli Ρ (1984). Acetylcholine receptor: an allosteric protein. Science 225: 1 3 3 3 - 1345. Claudio Τ, Ballivet M, Patrick J, Heinemann S (1983). Nucleotide and deduced amino acid sequences of Torpedo californica acetylcholine receptor y subunit. Proc Natl Acad Sei U S A 80: 1 1 1 1 - 1 1 1 5 .
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The first messengers responsible for the activation of cAMP-dependent protein kinase in muscle cells have not been established. Neurotransmitters and hormones that are known to stimulate intracellular c A M P levels have been considered. , 1987). , 1987; Laufer and Changeux, 1987). , 1989). Phosphorylation of the A C h R δ subunit in rat myotubes exposed to C G R P reached a maximum within 5 min and mimicked the time course of A C h R phosphorylation caused by forskolin. The CGRP-induced increase in A C h R a subunit phosphorylation was potentiated by phosphodiesterase inhibitors.
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